A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
University of Florida · Armed Forces Research Institute of Medical Science · +8 more institutions
Abstract
Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3)…
Citation impact
- FWCI
- 22.93
- Percentile
- 100%
- References
- 157
Authors
17Topics & keywords
- Coronavirus disease 2019 (COVID-19)
- Immunity
- Antibody
- Virology
- 2019-20 coronavirus outbreak
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Immunology
- Betacoronavirus
- Good health and well-being