Single-cell multiomics: technologies and data analysis methods

Advances in single-cell isolation and barcoding technologies offer unprecedented opportunities to profile DNA, mRNA, and proteins at a single-cell resolution. Recently, bulk multiomics analyses, such as multidimensional genomic and proteogenomic analyses, have proven beneficial for obtaining a comprehensive understanding of cellular events. This benefit has facilitated the development of single-cell multiomics analysis, which enables cell type-specific gene regulation to be examined. The cardinal features of single-cell multiomics analysis include (1) technologies for single-cell isolation, barcoding, and sequencing to measure multiple types of molecules from individual cells and (2) the integrative analysis…

• NR
  National Research Foundation

  Award: 2019R1A6A1A10073437
• NR
  National Research Foundation of Korea

  Awards: 2019R1A6A1A10073437, 2019M3A9B6066967, NRF-2019M3A9B6066967