NLRP3 inflammasome in endothelial dysfunction

Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate immune signal receptors to sense pathogens and initiate inflammatory responses under physiological and pathological conditions. The NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex. Its activation triggers the cleavage of pro-interleukin (IL)-1β and pro-IL-18, which are mediated by caspase-1, and secretes mature forms of these mediators from cells to promote the further inflammatory process and oxidative stress. Simultaneously, cells undergo pro-inflammatory programmed cell death, termed pyroptosis. The danger signals for activating NLRP3 inflammasome are…

• DO
  Department of Education of Shandong Province

  Award: J18KA285
• NN
  National Natural Science Foundation of China

  Awards: 81870331, 31701208, 91849209
• NS
  Natural Science Foundation of Shandong Province

  Awards: ZR2017MC067, 91849209
• QM
  Qingdao Municipal Science and Technology Bureau

  Award: 18-2-2-65-jch
• PO
  Project of Shandong Province Higher Educational Science and Technology Program

  Award: J18KA285