reviewNatural Product ReportsSep 16, 2020BRONZE OA

New developments in RiPP discovery, enzymology and engineering

MMManuel Montalbán‐LópezTAThomas Allan ScottSRSangeetha RameshIRImran R. RahmanAJAuke J. van Heel

Universidad de Granada · ETH Zurich · +39 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Covering: up to June 2020Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 described the emerging commonalities in the biosynthesis of RiPPs and the opportunities they offered for bioengineering and genome mining. Since then, the field has seen tremendous advances in understanding of the mechanisms by which nature assembles these compounds, in engineering their biosynthetic machinery for a wide range of applications, and in the discovery of entirely new RiPP families using bioinformatic tools developed specifically for this compound class. The First International Conference on RiPPs was held in 2019, and the…

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787
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36

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Topics
Keywords
  • Computational biology
  • Genome
  • Drug discovery
  • Computer science
  • Data science
  • Engineering
  • Biology
  • Bioinformatics
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