Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is activated by various stimuli, transducing a quick but transient transcriptional activity, to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory response. Meanwhile, the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily members. Since the activation of this pathway involves protein synthesis, the kinetics of non-canonical NF-κB activation is slow but persistent, in concordance with its biological functions in the development of immune cell and lymphoid organ, immune homeostasis and immune response. The activation of…

• NN
  National Natural Science Foundation of China

  Awards: 81871232, 91740111 and 81871232, 31870881, 91740111
• MO
  Ministry of Science and Technology of the People's Republic of China

  Awards: 2016YFA0502203, 2016YFA0502201,2019YFA0110201, 2019YFA0110203, 2018YFE0204500 and 2018YFC1004601, 2019YFA0110203
• SU
  Sichuan University
• NK
  National Key Research and Development Program of China

  Awards: 2016YFA0502203, 2019YFA0110203
• WC
  West China Hospital, Sichuan University

  Award: 1.3.5