articleCell ReportsSep 19, 2020GOLD OA

Evasion of Type I Interferon by SARS-CoV-2

HXHongjie XiaZCZengguo CaoXXXuping XieXZXianwen ZhangJYJohn Yun-Chung Chen

The University of Texas Medical Branch at Galveston · Jilin University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening to identify SARS-CoV-2 proteins that antagonize type I interferon (IFN-I) response. We found three proteins that antagonize IFN-I production via distinct mechanisms: nonstructural protein 6 (nsp6) binds TANK binding kinase 1 (TBK1) to suppress interferon regulatory factor 3 (IRF3) phosphorylation, nsp13 binds and blocks TBK1 phosphorylation, and open reading frame 6 (ORF6) binds importin Karyopherin α 2 (KPNA2) to inhibit IRF3 nuclear translocation. We identify two…

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1,026
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Authors

9

Topics & keywords

Topics
Keywords
  • STAT1
  • Biology
  • IRF3
  • Interferon
  • STAT2
  • Interferon regulatory factors
  • Virology
  • Coronavirus
UN Sustainable Development Goals
  • Good health and well-being
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