Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Protein-protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. Therefore, targeting PPIs is a direction in treating diseases and an essential strategy for the development of new drugs. In the past few decades, the modulation of PPIs has been recognized as one of the most challenging drug discovery tasks. In recent years, some PPIs modulators have entered clinical studies, some of which been approved for marketing, indicating that the modulators targeting PPIs have broad prospects. Here, we summarize the recent advances in PPIs modulators, including small…

• DO
  Department of Science and Technology of Sichuan Province

  Award: 2019YFS0514
• SA
  State Administration of Traditional Chinese Medicine of the People's Republic of China

  Award: JDZX2015210
• CU
  Chengdu University of Traditional Chinese Medicine

  Award: 2018GZ2011005
• CS
  Chengdu Science and Technology Bureau

  Award: No. 2015-HM01-00463-SF
• CU
  Chengdu University
• CS
  Chengdu Science and Technology Program