articleScienceSep 24, 2020HYBRID OA

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

QZQian ZhangPBPaul BastardZLZhiyong LiuJLJérémie Le PenMMMarcela Moncada‐Vélez

Rockefeller University · Inserm · +76 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang et al. used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and…

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Topics & keywords

Topics
Keywords
  • Coronavirus disease 2019 (COVID-19)
  • Immunity
  • 2019-20 coronavirus outbreak
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Medicine
  • Immunology
  • Virology
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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