A guide to assessing cellular senescence in vitro and in vivo
University of Cambridge · Hutchison/MRC Research Centre
Abstract
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly dynamic and regulated cellular state plays beneficial roles in physiology, such as during embryonic development and wound healing, but it can also result in antagonistic effects in age-related pathologies, degenerative disorders, ageing and cancer. In an effort to better identify this complex state, and given that a universal marker has yet to be identified, a general set of hallmarks describing senescence has been established. However, as the senescent programme becomes more defined, further complexities, including phenotype…
Citation impact
- FWCI
- 29.56
- Percentile
- 100%
- References
- 165
Authors
4Topics & keywords
- In vivo
- Senescence
- In vitro
- Cell biology
- Cellular senescence
- Cellular Aging
- Chemistry
- Biology