articleScienceSep 24, 2020HYBRID OA

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

PBPaul BastardLBLindsey B. RosenQZQian ZhangEMEleftherios MichailidisHHHans-Heinrich Hoffmann

Inserm · Université Paris Cité · +63 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang et al. used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and…

Citation impact

2,835
total citations
FWCI
57.94
Percentile
100%
References
48
Citations per year

Authors

752

Topics & keywords

Topics
Keywords
  • Autoantibody
  • Immunology
  • Asymptomatic
  • Medicine
  • Pneumonia
  • Antibody
  • Phenocopy
  • Coronavirus
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding