Cells of the adult human heart

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized…

• NS
  National Science Foundation

  Awards: EEC-1647837, 1647837
• HH
  Howard Hughes Medical Institute
• HA
  Heart and Stroke Foundation of Canada
• AV
  Alexander von Humboldt-Stiftung
• DZ
  Deutsches Zentrum für Herz-Kreislaufforschung

  Award: SP/19/1/34461
• SC
  Sarnoff Cardiovascular Research Foundation
• CZ
  Chan Zuckerberg Initiative
• UO
  University of Alberta
• BH
  British Heart Foundation

  Awards: PG/17/71/33242, PG/15/57/31580, PG/16/47/32156
• EC
  European Commission
• DF
  Deutsche Forschungsgemeinschaft

  Award: 13/12
• BF
  Bundesministerium für Bildung und Forschung

  Award: 031L0075A
• CS
  China Scholarship Council
• AI
  Alberta Innovates
• NI
  National Institutes of Health
• CI
  Canadian Institutes of Health Research