reviewCell Death and DiseaseSep 25, 2020GOLD OA

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

PRPatricia RadaÁGÁgueda González‐RodríguezCGCarmelo García‐MonzónÁMÁngela M. Valverde

Instituto de Salud Carlos III · Instituto de Investigaciones Biomédicas Sols-Morreale · +5 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma. One of the crucial events clearly involved in NAFLD progression is the lipotoxicity resulting from an excessive fatty acid (FFA) influx to hepatocytes. Hepatic lipotoxicity occurs when the capacity of the hepatocyte to manage and export FFAs as triglycerides (TGs) is overwhelmed. This review provides succinct insights into the molecular mechanisms responsible for lipotoxicity in NAFLD, including ER and oxidative stress, autophagy, lipoapotosis and inflammation.…

Citation impact

493
total citations
FWCI
32.97
Percentile
100%
References
166
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Lipotoxicity
  • Steatohepatitis
  • CD36
  • Fatty liver
  • Steatosis
  • Internal medicine
  • Cirrhosis
  • Hepatocellular carcinoma
UN Sustainable Development Goals
  • Good health and well-being
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