Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

Tortorici, M. Alejandra; Beltramello, Martina; Lempp, Florian A.; Pinto, Dora; Dang, Ha V.; Rosen, Laura E.; McCallum, Matthew; Bowen, John E.; Minola, Andrea; Jaconi, Stefano; Zatta, Fabrizia; Marco, Anna De; Guarino, Barbara; Bianchi, Siro; Lauron, Elvin J.; Tucker, Heather; Zhou, Jiayi; Peter, Alessia; Havenar‐Daughton, Colin; Wojcechowskyj, Jason A.; Case, James Brett; Chen, Rita E.; Kaiser, Hannah; Montiel-Ruiz, Martin; Meury, Marcel; Czudnochowski, Nadine; Spreafico, Roberto; Dillen, Josh R.; Ng, Cindy; Sprugasci, Nicole; Culap, Katja; Benigni, Fabio; Abdelnabi, Rana; Foo, Caroline S.; Schmid, Michael; Cameroni, Elisabetta; Riva, Agostino; Gabrieli, Arianna; Galli, Massimo; Pizzuto, Matteo Samuele; Neyts, Johan; Diamond, Michael; Virgin, Herbert W.; Snell, Gyorgy; Corti, Davide; Fink, Katja; Veesler, David

doi:10.1126/science.abe3354

articleScienceSep 24, 2020HYBRID OA

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

MAM. Alejandra Tortorici MBMartina Beltramello FAFlorian A. Lempp DPDora Pinto HVHa V. Dang

Centre National de la Recherche Scientifique · Institut Pasteur · +8 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 September 2020. We report the isolation and characterization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-CoV-2 challenge. Cryo-electron microscopy structures show that S2E12 and S2M11 competitively block angiotensin-converting enzyme 2 (ACE2) attachment and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epitope spanning two adjacent receptor-binding domains. Antibody cocktails that include S2M11, S2E12, or the previously…

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Topics & keywords

Topics

Keywords

Antibody
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Virology
Epitope
Severe acute respiratory syndrome
Coronavirus
Biology
Effector

UN Sustainable Development Goals

Good health and well-being

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