Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study

•Patients with cirrhosis experience high rates of hepatic decompensation and death following SARS-CoV-2 infection.•Mortality increased in stepwise fashion according to Child-Pugh class.•Other risk factors for death included advancing age and alcohol-related liver disease.•Mortality risk was higher in patients with advanced cirrhosis than propensity-score-matched controls without liver disease.•The majority of deaths in patients with cirrhosis were from COVID-19-related lung disease. Background & AimsChronic liver disease (CLD) and cirrhosis are associated with immune dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes following SARS-CoV-2 infection. We aimed to…

• WT
  Wellcome Trust
• GS
  Gastroenterological Society of Australia
• EA
  European Association for the Study of the Liver
• BL
  British Liver Trust
• UE
  United European Gastroenterology
• NI
  National Institutes of Health
• NO
  NIHR Oxford Biomedical Research Centre
• NC
  North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill