The role of microenvironment in tumor angiogenesis

Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment-composed of tumor cells, surrounding cells, and secreted cytokines-provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic…

• NN
  National Natural Science Foundation of China

  Awards: 81702907, 81872278, 2018SK21210, 81972776, 2018JJ3815, 81803025, 81772928, 2019JJ50872, 81772901, 2019JJ50354, 2018SK21211, 2018JJ3704
• CS
  Central South University
• NS
  Natural Science Foundation of Hunan Province

  Awards: 2018SK21211, 2018SK21210, 2020JJ4125, 2018JJ3704, 2019JJ50778, 2019JJ50354, 2019JJ50872, 2018JJ3815
• HE
  Higher Education Discipline Innovation Project
• FR
  Fundamental Research Funds for Central Universities of the Central South University

  Awards: 2019zzts325, 2019zzts319
• OE
  Overseas Expertise Introduction Project for Discipline Innovation

  Awards: 111 Project, 111 Project, No. 111-2-12