Concepts of extracellular matrix remodelling in tumour progression and metastasis
University of California, San Francisco · UCSF Helen Diller Family Comprehensive Cancer Center
Abstract
Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing…
Citation impact
- FWCI
- 87.00
- Percentile
- 100%
- References
- 305
Authors
4- JWJuliane WinklerCorresponding
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- AAAbisola Abisoye-Ogunniyan
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- KJKevin J. Metcalf
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- ZWZena Werb
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
Topics & keywords
- Extracellular matrix
- Stromal cell
- Metastasis
- Cell biology
- Cancer research
- Tumor microenvironment
- Cell migration
- Desmoplasia