Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
University of Toronto · Mount Sinai Hospital · +10 more institutions
Abstract
While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody response in saliva and its relationship to systemic antibody levels. Here, we profiled by enzyme-linked immunosorbent assays (ELISAs) IgG, IgA and IgM responses to the SARS-CoV-2 spike protein (full length trimer) and its receptor-binding domain (RBD) in serum and saliva of acute and convalescent patients with laboratory-diagnosed COVID-19 ranging from 3-115 days post-symptom onset (PSO), compared to negative controls. Anti-SARS-CoV-2 antibody responses were readily detected in serum and saliva, with peak IgG levels attained by 16-30 days PSO. Longitudinal analysis revealed that…
Citation impact
- FWCI
- 19.82
- Percentile
- 100%
- References
- 60
Authors
36- BIBaweleta IshoCorresponding
University of Toronto
- KTKento T. AbeCorresponding
Mount Sinai Hospital, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- MZMichelle ZuoCorresponding
University of Toronto
- AJAlainna JamalCorresponding
Mount Sinai Hospital, University of Toronto, Sinai Health System
- BRBhavisha Rathod
Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
Topics & keywords
- Saliva
- Persistence (discontinuity)
- Virology
- Coronavirus disease 2019 (COVID-19)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Antibody
- 2019-20 coronavirus outbreak
- Antigen