reviewDiabetes Metabolic Syndrome and ObesityOct 1, 2020GOLD OA

<p>Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications</p>

YTYohannes Tsegyie Wondmkun

Addis Ababa University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of insulin resistance are released by adipose tissue. Besides, endoplasmic reticulum stress, adipose tissue hypoxia, oxidative stress, lipodystrophy, and genetic background have a role in insulin resistance. However, no effective drug therapy was developed for type 2 diabetes mellitus targeting these physiological factors. This is might be due to a lack of agreement on the comprehensive mechanism of insulin resistance. Therefore, this review assesses the cellular…

Citation impact

679
total citations
FWCI
29.20
Percentile
100%
References
45
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Insulin resistance
  • Adipose tissue
  • Endocrinology
  • Internal medicine
  • Obesity
  • Diabetes mellitus
  • Insulin
  • Type 2 diabetes
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding