reviewBiomoleculesOct 9, 2020GOLD OA

Role of Glutathione in Cancer: From Mechanisms to Therapies

LSLuke S KennedyJKJagdeep K. SandhuMHMary‐Ellen HarperMČMiroslava Čuperlović‐Culf

University of Ottawa · National Research Council Canada

PubMed
Indexed incrossrefdoajpubmed

Abstract

Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, and xenobiotics. Recent studies have highlighted the importance of GSH in key signal transduction reactions as a controller of cell differentiation, proliferation, apoptosis, ferroptosis and immune function. Molecular changes in the GSH antioxidant system and disturbances in GSH homeostasis have been implicated in tumor initiation, progression, and treatment response. Hence, GSH has both protective and pathogenic…

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834
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Authors

4

Topics & keywords

Topics
Keywords
  • Glutathione
  • Reactive oxygen species
  • Antioxidant
  • Chemistry
  • Cancer cell
  • Cell biology
  • Pharmacology
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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