SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Banerjee, Abhik K.; Blanco, Mario R.; Bruce, Emily A.; Honson, Drew D.; Chen, Linlin M.; Chow, Amy; Bhat, Prashant; Ollikainen, Noah; Quinodoz, Sofia A.; Loney, Colin; Thai, Jasmine; Miller, Zachary D.; Lin, Aaron E.; Schmidt, Madaline M.; Stewart, Douglas G.; Goldfarb, Daniel; Lorenzo, Giuditta De; Rihn, Suzannah J.; Voorhees, R.M.; Botten, Jason; Majumdar, Devdoot; Guttman, Mitchell

doi:10.1016/j.cell.2020.10.004

articleCellOct 8, 2020HYBRID OA

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

AKAbhik K. Banerjee MRMario R. Blanco EAEmily A. Bruce DDDrew D. Honson LMLinlin M. Chen

University of Southern California · California Institute of Technology · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19). Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis. Here, we comprehensively define the interactions between SARS-CoV-2 proteins and human RNAs. NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infection. Finally, NSP8 and NSP9 bind to the 7SL RNA in the…

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637

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Topics & keywords

Topics

Keywords

Biology
RNA splicing
Translation (biology)
RNA
Coronavirus
Messenger RNA
RNA-binding protein
Ribosome

UN Sustainable Development Goals

Good health and well-being

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