Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression
Shandong University · Shandong Provincial Hospital · +1 more institution
Abstract
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands. Recently, extracellular vesicles (EVs) known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment (TME). Meanwhile, the TME is a highly heterogeneous ecosystem incorporating cancer cells, fibroblasts, adipocytes, endothelial cells, mesenchymal stem cells, and extracellular matrix. Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells, which facilitate cancer progression, angiogenesis, metastasis, drug resistance, and…
Citation impact
- FWCI
- 16.00
- Percentile
- 100%
- References
- 145
Authors
6- EYEnli YangCorresponding
Shandong University, Shandong Provincial Hospital, Shandong First Medical University
- XWXuan Wang
Shandong University, Shandong Provincial Hospital, Shandong First Medical University
- ZGZhiyuan Gong
Shandong University, Shandong Provincial Hospital, Shandong First Medical University
- MYMiao Yu
Shandong University, Shandong Provincial Hospital, Shandong First Medical University
- HWHaiwei Wu
Shandong Provincial Hospital, Shandong First Medical University
Topics & keywords
- Microvesicles
- Reprogramming
- Tumor microenvironment
- Angiogenesis
- Cancer cell
- Cancer research
- Metastasis
- Exosome