The nucleus acts as a ruler tailoring cell responses to spatial constraints
Centre National de la Recherche Scientifique · King's College London · +16 more institutions
Abstract
The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler-based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler…
Citation impact
- FWCI
- 33.32
- Percentile
- 100%
- References
- 52
Authors
21- AJAlexis J. LomakinCorresponding
Centre National de la Recherche Scientifique, King's College London, Université Paris Sciences et Lettres, St Anna Children's Hospital, CeMM Research Center for Molecular Medicine, Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Biologie cellulaire et Cancer, St. Anna Children's Cancer Research Institute, Medical University of Vienna, Institut Curie
- CJCédric J. CattinCorresponding
ETH Zurich
- DCDamien CuvelierCorresponding
Centre National de la Recherche Scientifique, Université Paris Sciences et Lettres, Institut Pierre-Gilles de Gennes pour la Microfluidique, Biologie cellulaire et Cancer, Institut Curie
- ZAZahraa AlraiesCorresponding
Centre National de la Recherche Scientifique, Inserm, Université Paris Sciences et Lettres, Institut Pierre-Gilles de Gennes pour la Microfluidique, Biologie cellulaire et Cancer, Institut Curie
- MMMarc Molina-Jordán
King's College London
Topics & keywords
- Nucleus
- Mechanotransduction
- Cell biology
- Contractility
- Cell
- Cell nucleus
- Chemistry
- Biophysics
Funding
- CPCancer Prevention and Research Institute of TexasAward: RR160057
- QMQueen Mary University of London
- KCKing's College London
- ECEuropean CommissionAwards: 751735, FP7/2007-2013, ANR-10-IDEX-0001-02 PSL, 609102, 2007-2013, PCOFUND-GA-2013-609102, FP7/2007
- HFHuman Frontier Science ProgramAward: LT000305/2018-L
- ANAgence Nationale de la RechercheAwards: ANR-10-IDEX-, ANR-10-IDEX-0001-02 PSL, ANR-10-IDEX-0001-02, ANR-10-IDEX-0001, 10-IDEX-0001-02 PSL, 10-LABX-31, 10-IDEX-0001-02, 10-EQPX-34, ANR-10-IDEX, ANR-10, ANR-10-EQPX-34, IDEX-0001-02, ANR-10-EQPX, ANR-10-LABX-31
- INInstitut National de la Santé et de la Recherche MédicaleAwards: ANR-10-IDEX-0001-02, ANR-10-IDEX-0001-02 PSL, ANR-10-LABX-31
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- FAFondation ARC pour la Recherche sur le CancerAward: DOC20190508743
- ÖFÖsterreichische Forschungsförderungsgesellschaft
- INInstitut National Du CancerAward: ANR-10-IDEX-0001-02 PSL
- CFCampus FranceAward: PCOFUND-GA-2013-609102
- IPInstitut Pierre-Gilles de GennesAwards: ANR-10, ANR-10-IDEX-0001-02, ANR-10-EQPX-34, ANR-10-IDEX-0001-02 PSL, ANR-10-LABX-31
- NINational Institutes of HealthAwards: FP7/2007-2013, K99GM123221, R35GM133522-01, R33CA235254, -0001, R35GM133522, R01GM126054, R33CA235254-02
- MCMenzies Centre for Australian Studies, King's College London, University of London
- IDInstituto de Salud Carlos IIIAwards: PI20/00306, PI17/01395
- IOInstitute of Molecular and Cell Biology
- NINational Institute of General Medical SciencesAwards: K99GM123221, R01GM126054, R35GM133522
- HEH2020 European Research CouncilAward: 311205
- HMH2020 Marie Skłodowska-Curie ActionsAwards: PCOFUND-GA-2013-609102, FP7/2007-2013