Comparative Toxicogenomics Database (CTD): update 2021

The public Comparative Toxicogenomics Database (CTD; http://ctdbase.org/) is an innovative digital ecosystem that relates toxicological information for chemicals, genes, phenotypes, diseases, and exposures to advance understanding about human health. Literature-based, manually curated interactions are integrated to create a knowledgebase that harmonizes cross-species heterogeneous data for chemical exposures and their biological repercussions. In this biennial update, we report a 20% increase in CTD curated content and now provide 45 million toxicogenomic relationships for over 16 300 chemicals, 51 300 genes, 5500 phenotypes, 7200 diseases and 163 000 exposure events, from 600 comparative species. Furthermore,…

• NI
  National Institutes of Health

  Awards: R01 ES014065, P30 ES025128, R01 ES023788, ES025128
• NI
  National Institute of Environmental Health Sciences

  Awards: R01 ES023788, P30 ES025128, R01 ES014065