Candida auris: Epidemiology, biology, antifungal resistance, and virulence

First described in 2009 in Japan, the emerging multidrug-resistant fungal pathogen Candida auris is becoming a worldwide public health threat that has been attracting considerable attention due to its rapid and widespread emergence over the past decade. The reasons behind the recent emergence of this fungus remain a mystery to date. Genetic analyses indicate that this fungal pathogen emerged simultaneously in several different continents, where 5 genetically distinct clades of C. auris were isolated from distinct geographical locations. Although C. auris belongs to the CTG clade (its constituent species translate the CTG codon as serine instead of leucine, as in the standard code), C. auris is a haploid fungal…

• NS
  Natural Science Foundation of Shanghai

  Award: 19ZR1405100
• NN
  National Natural Science Foundation of China

  Awards: 31625002, 31930005, 31930005 and 31625002
• NI
  National Institutes of Health

  Awards: R35GM124594, F31DE028488, R21AI125801