articleScienceOct 20, 2020HYBRID OA

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

LCLudovico Cantuti‐CastelvetriRORavi OjhaLDLiliana D. PedroMDMinou DjannatianJFJonas Franz

German Center for Neurodegenerative Diseases · University of Helsinki · +19 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Another host factor for SARS-CoV-2 Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a receptor; however, their tissue tropism differs, raising the possibility that additional host factors are involved. The spike protein of SARS-CoV-2 contains a cleavage site for the protease furin that is absent from SARS-CoV (see the Perspective by Kielian). Cantuti-Castelvetri et al. now show that neuropilin-1 (NRP1), which is known to bind furin-cleaved substrates, potentiates SARS-CoV-2 infectivity. NRP1 is abundantly expressed in the respiratory and olfactory…

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Topics & keywords

Topics
Keywords
  • Furin
  • Tropism
  • Neuropilin 1
  • Viral entry
  • Biology
  • Virology
  • Coronavirus
  • Infectivity
UN Sustainable Development Goals
  • Good health and well-being
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