Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with…

• JF
  JPB Foundation
• OP
  Open Philanthropy Project

  Award: #2020-215611
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: HHSN272201400008C, 75N93019C00051