MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases
National Institutes of Health · National Institute on Alcohol Abuse and Alcoholism
Abstract
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression by binding to specific mRNA targets and promoting their degradation and/or translational inhibition. miRNAs regulate both physiological and pathological liver functions. Altered expression of miRNAs is associated with liver metabolism dysregulation, liver injury, liver fibrosis and tumour development, making miRNAs attractive therapeutic strategies for the diagnosis and treatment of liver diseases. Here, we review recent advances regarding the regulation and function of miRNAs in liver diseases with a major focus on miRNAs that are specifically expressed or enriched in hepatocytes (miR-122, miR-194/192),…
Citation impact
- FWCI
- 22.48
- Percentile
- 100%
- References
- 107
Authors
4- XWXiaolin Wang
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism
- YHYong He
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism
- BMBryan Mackowiak
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism
- BGBin GaoCorresponding
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism
Topics & keywords
- microRNA
- Liver injury
- Liver disease
- Biology
- Fatty liver
- MiR-122
- Alcoholic liver disease
- Hepatocellular carcinoma
- Good health and well-being