Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

Guo, Hao; Chou, Wei-Chun; Lai, Yunjia; Liang, Kaixin; Tam, Jason W.; Brickey, W. June; Chen, Liang; Montgomery, Nathan D.; Li, Xin; Bohannon, Lauren; Sung, Anthony D.; Chao, Nelson J.; Peled, Jonathan U.; Gomes, Antonio L. C.; Brink, Marcel R.M. van den; French, Matthew J.; Macintyre, Andrew N.; Sempowski, Gregory D.; Tan, Xianming; Sartor, R. Balfour; Lü, Kun; Ting, Jenny P.‐Y.

doi:10.1126/science.aay9097

articleScienceOct 29, 2020GREEN OA

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

HGHao Guo WCWei-Chun Chou YLYunjia Lai KLKaixin Liang JWJason W. Tam

University of North Carolina at Chapel Hill · Duke University · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Radioprotective bacteria A common symptom of radiation treatment for cancer is gastrointestinal disruption. The damage caused can become so severe and debilitating that it interrupts treatment. Guo et al. noticed that mice surviving experimental radiation exposure had distinctive taxonomic representation in their gut microbiota. A similar correlation was also observed in a small group of human subjects. Further experiments in mice revealed that some strains of bacteria produced high levels of short-chain fatty acids, which seemed to be dampening inflammatory responses and alleviating the damage caused by reactive oxygen species released by the radiation. A metabolomics analysis also implicated a role for…

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Topics

Keywords

Acute Radiation Syndrome
Ionizing radiation
Biology
Population
Radiation dose
Haematopoiesis
Physiology
Medicine

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