Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been considered as primarily a disease of the articular cartilage, the participation of subchondral bone in the pathogenesis of OA has attracted increasing attention. This review summarises the microstructural and histopathological changes in subchondral bone during OA progression that are due, at the cellular level, to changes in the interactions among osteocytes, osteoblasts, osteoclasts (OCs), endothelial cells and sensory neurons. Therefore, we focus on how pathological cellular interactions in the subchondral bone microenvironment promote subchondral bone destruction at different stages of OA progression. In addition, the…

• NN
  National Natural Science Foundation of China

  Awards: 31870962, 81930067
• TM
  Third Military Medical University

  Award: 2018XYY05
• SH
  Southwest Hospital

  Award: SWH2018LJ-03
• KP
  Key Programme