articleScienceNov 6, 2020HYBRID OA

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

KWKevin W. NgNFNikhil FaulknerGHGeorgina H. CornishARAnnachiara RosaRHRuth Harvey

The Francis Crick Institute · University College London Hospitals NHS Foundation Trust · +7 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable using a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. They were predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit. By contrast, SARS-CoV-2 infection induced higher titers of SARS-CoV-2 S-reactive IgG antibodies targeting both the S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation period.…

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984
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100%
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Authors

47

Topics & keywords

Topics
Keywords
  • Antibody
  • Immunity
  • Humoral immunity
  • Immunology
  • Virology
  • Biology
  • Immune system
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
UN Sustainable Development Goals
  • Good health and well-being
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