LncRNA‐mediated posttranslational modifications and reprogramming of energy metabolism in cancer
Sun Yat-sen University · Sun Yat-sen University Cancer Center · +3 more institutions
Abstract
Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors. It is well recognized that long noncoding RNAs (lncRNAs) regulate energy metabolism in cancer. However, lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present. In this review, we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes, transcription factors, and other proteins involved in metabolic pathways. In addition, we discuss the mechanisms through which these interactions…
Citation impact
- FWCI
- 24.49
- Percentile
- 100%
- References
- 92
Authors
6- YTYue‐Tao Tan
Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China
- JLJin‐Fei Lin
Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China
- TLTing Li
Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China
- JLJiajun Li
Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China
- RXRui‐Hua XuCorresponding
Academy of Medical Sciences, Sun Yat-sen University, Chinese Academy of Medical Sciences & Peking Union Medical College, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China
Topics & keywords
- Reprogramming
- Biology
- Cancer
- Metabolic pathway
- Computational biology
- Energy metabolism
- Transcription factor
- Cancer cell
- Affordable and clean energy