Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes
Amsterdam UMC Location University of Amsterdam · Child and Family Research Institute · +2 more institutions
Abstract
The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D). The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only partly understood. It becomes progressively clear that T2D is characterized by a chronic state of low-grade inflammation, which has been linked to the development of insulin resistance. Here, we review the current evidence that intestinal microbiota, and the metabolites they produce, could drive the development of insulin resistance in obesity and T2D, possibly by initiating an inflammatory response. First, we will summarize major findings about immunological and gut microbial changes in these metabolic diseases. Next, we will give…
Citation impact
- FWCI
- 25.59
- Percentile
- 100%
- References
- 365
Authors
7- TPTorsten P. M. ScheithauerCorresponding
Amsterdam UMC Location University of Amsterdam
- ERElena Rampanelli
Amsterdam UMC Location University of Amsterdam
- MNMax Nieuwdorp
Amsterdam UMC Location University of Amsterdam
- BABruce A. Vallance
Child and Family Research Institute
- CBC. Bruce Verchere
University of British Columbia, BC Children's Hospital
Topics & keywords
- Gut flora
- Insulin resistance
- Immune system
- Inflammation
- Type 2 diabetes
- Obesity
- Immunology
- Disease
- Good health and well-being