Deciphering cell–cell interactions and communication from gene expression
Foundation Center · University of California San Diego · +3 more institutions
Abstract
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell functions. When cells do not properly interact or improperly decode molecular messages, disease ensues. Thus, the identification and quantification of intercellular signalling pathways has become a common analysis performed across diverse disciplines. The expansion of protein–protein interaction databases and recent advances in RNA sequencing technologies have enabled routine analyses of intercellular signalling from gene expression measurements of bulk and single-cell data sets. In particular, ligand–receptor pairs can be used to infer intercellular communication from the coordinated expression of their cognate genes. In…
Citation impact
- FWCI
- 52.35
- Percentile
- 100%
- References
- 185
Authors
4- EAErick ArmingolCorresponding
Foundation Center, University of California San Diego, Novo Nordisk (United States)
- AOAdam Officer
University of California San Diego
- OHOlivier Harismendy
University of California San Diego
- NENathan E. Lewis
Novo Nordisk Foundation, Foundation Center, University of California San Diego, Novo Nordisk (United States), La Jolla Bioengineering Institute
Topics & keywords
- Biology
- Computational biology
- Transcriptome
- Context (archaeology)
- Cell
- Gene expression
- Identification (biology)
- Intracellular