Rfam 14: expanded coverage of metagenomic, viral and microRNA families

Rfam is a database of RNA families where each of the 3444 families is represented by a multiple sequence alignment of known RNA sequences and a covariance model that can be used to search for additional members of the family. Recent developments have involved expert collaborations to improve the quality and coverage of Rfam data, focusing on microRNAs, viral and bacterial RNAs. We have completed the first phase of synchronising microRNA families in Rfam and miRBase, creating 356 new Rfam families and updating 40. We established a procedure for comprehensive annotation of viral RNA families starting with Flavivirus and Coronaviridae RNAs. We have also increased the coverage of bacterial and metagenome-based RNA…

• CD
  California Department of Fish and Game

  Award: MA5082/7-1
• C
  Carl-Zeiss-Stiftung

  Award: 0563-2.8/738/2
• JL
  Justus Liebig Universität Gießen
• UW
  Universität Wien
• NI
  National Institutes of Health
• H2
  Horizon 2020 Framework Programme

  Award: 654039
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/M011690/1, BB/S020268/1, BB/S020462/1, BB/M011690/1, BB/S020462/1
• NH
  National Human Genome Research Institute

  Award: R01-HG009116