Progressive Cactus is a multiple-genome aligner for the thousand-genome era

Abstract New genome assemblies have been arriving at a rapidly increasing pace, thanks to decreases in sequencing costs and improvements in third-generation sequencing technologies 1–3 . For example, the number of vertebrate genome assemblies currently in the NCBI (National Center for Biotechnology Information) database 4 increased by more than 50% to 1,485 assemblies in the year from July 2018 to July 2019. In addition to this influx of assemblies from different species, new human de novo assemblies 5 are being produced, which enable the analysis of not only small polymorphisms, but also complex, large-scale structural differences between human individuals and haplotypes. This coming era and its unprecedented…

• NI
  National Institutes of Health

  Awards: U01HL137183, R01HG010485, 5T32HG008345-04, 2U41HG007234, U41HG010972, U01HG010961, 5U54HG007990