Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies
MRC Centre for Environment and Health · Imperial College London · +3 more institutions
Abstract
Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lymphocyte ratio (NLR) or tumour-associated neutrophils (TAN) and cancer prognosis.
We searched MEDLINE, Embase and Cochrane Database of Systematic Reviews from inception to 29 May 2020 for systematic reviews and meta-analyses of observational studies on neutrophil counts (here NLR or TAN) and specific cancer outcomes related to disease progression or survival. The available evidence was graded as strong, highly suggestive, suggestive, weak or uncertain through the application of pre-set GRADE criteria.
Citation impact
- FWCI
- 21.22
- Percentile
- 100%
- References
- 136
Authors
6- MAMeghan A. CuppCorresponding
MRC Centre for Environment and Health, Imperial College London
- MCMargarita Cariolou
MRC Centre for Environment and Health, Imperial College London
- ITIoanna Tzoulaki
University of Ioannina, MRC Centre for Environment and Health, Imperial College London
- DADagfinn Aune
Oslo University Hospital, Oslo Nye Høyskole, MRC Centre for Environment and Health, Imperial College London
- ΕΕΕvangelos Εvangelou
University of Ioannina, MRC Centre for Environment and Health, Imperial College London
Topics & keywords
- Medicine
- Observational study
- Meta-analysis
- Systematic review
- Neutrophil to lymphocyte ratio
- Cancer
- Intensive care medicine
- Oncology