Targeting immunogenic cell death in cancer
Cancer Research UK Scotland Institute · University of Glasgow
Abstract
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts. ICD comprises the release of damage-associated molecular patterns (DAMPs) from dying tumor cells that result in the activation of tumor-specific immune responses, thus eliciting long-term efficacy of anticancer drugs by combining direct cancer cell killing and antitumor immunity. Remarkably, subcutaneous injection of dying tumor cells undergoing ICD has been shown to provoke anticancer vaccine effects in vivo. DAMPs include the cell…
Citation impact
- FWCI
- 30.29
- Percentile
- 100%
- References
- 65
Authors
2Topics & keywords
- Immunogenic cell death
- Oncolytic virus
- Immune system
- Programmed cell death
- Cancer research
- Cancer cell
- Cancer
- Immunotherapy
- Good health and well-being