Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Ramasamy, Maheshi N; Minassian, Angela M; Ewer, Katie J; Flaxman, Amy L; Folegatti, Pedro M; Owens, Daniel R; Voysey, Merryn; Aley, Parvinder K; Angus, Brian; Babbage, Gavin; Belij-Rammerstorfer, Sandra; Berry, Lisa; Bibi, Sagida; Bittaye, Mustapha; Cathie, Katrina; Chappell, Harry; Charlton, Sue; Cicconi, Paola; Clutterbuck, Elizabeth A; Colin-Jones, Rachel; Dold, Christina; Emary, Katherine R W; Fedosyuk, Sofiya; Fuskova, Michelle; Gbesemete, Diane; Green, Catherine; Hallis, Bassam; Hou, Mimi M; Jenkin, Daniel; Joe, Carina C D; Kelly, Elizabeth J; Kerridge, Simon; Lawrie, Alison M; Lelliott, Alice; Lwin, May N; Makinson, Rebecca; Marchevsky, Natalie G; Mujadidi, Yama; Munro, Alasdair P S; Pacurar, Mihaela; Plested, Emma; Rand, Jade; Rawlinson, Thomas; Rhead, Sarah; Robinson, Hannah; Ritchie, Adam J; Ross-Russell, Amy L; Saich, Stephen; Singh, Nisha; Smith, Catherine C; Snape, Matthew D; Song, Rinn; Tarrant, Richard; Themistocleous, Yrene; Thomas, Kelly M; Villafana, Tonya L; Warren, Sarah C; Watson, Marion E E; Douglas, Alexander D; Hill, Adrian V S; Lambe, Teresa; Gilbert, Sarah C; Faust, Saul N; Pollard, Andrew J; Aboagye, Jeremy; Adams, Kelly; Ali, Aabidah; Allen, Elizabeth R.; Allen, Lauren; Allison, Jennifer L.; Andritsou, Foteini; Anslow, Rachel; Arbe-Barnes, Edward H.; Baker, Megan; Baker, Natalie; Baker, Philip; Baleanu, Ioana; Barker, Debbie; Barnes, Eleanor; Barrett, Jordan R.; Barrett, Kelly; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beckley, Rebecca; Bellamy, Duncan; Berg, Adam; Bermejo, Laura; Berrie, Eleanor; Beveridge, Amy; Bewley, Kevin; Bijker, Else M.; Birch, Geeta; Blackwell, Luke; Bletchly, Heather; Blundell, Caitlin L.; Blundell, Susannah R.; Bolam, Emma; Boland, Elena; Bormans, Daan; Borthwick, Nicola; Boukas, Konstantinos; Bower, Thomas; Bowring, Francesca; Boyd, Amy; Brenner, Tanja; Brown, Phillip; Brown-O'Sullivan, Charlie; Bruce, Scott; Brunt, Emily; Burbage, Jamie; Burgoyne, Joshua; Buttigieg, Karen R.; Byard, Nicholas; Puig, Ingrid Cabera; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Carr, Melanie; Carroll, Miles W.; Cashen, Paul; Cavey, Ana; Chadwick, Jim; Challis, Ruth; Chapman, David; Charles, David; Chelysheva, Irina; Cho, Jee-Sun; Cifuentes, Liliana; Clark, Elizabeth; Collins, Sarah; Conlon, Christopher P.; Coombes, Naomi S.; Cooper, Rachel; Cooper, Cushla; Crocker, Wendy E.M.; Crosbie, Sarah; Cullen, Dan; Cunningham, Christina; Cuthbertson, Fiona; Datoo, Brad E.; Dando, Lynne; Datoo, Mehreen S.; Datta, Chandrabali; Davies, Hannah; Davies, Sarah; Davis, Elizabeth J.; Davis, Judith; Dearlove, David; Demissie, Tesfaye; Marco, Stefania Di; Maso, Claudio Di; DiTirro, Danielle; Docksey, Claire; Dong, Tao; Donnellan, Francesca R.; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Drury, Ruth E.; Dunachie, Susanna J.; Edwards, Christopher J.; Edwards, Nick J.; Muhanna, Omar El; Elias, Sean C.; Elliott, Ryan S.; Elmore, Michael J.; English, Marcus Rex; Felle, Sally; Feng, Shuo; Silva, Carla Ferreira Da; Field, Samantha; Fisher, Richard; Fixmer, Carine; Ford, Karen J.; Fowler, Jamie; Francis, Emma; Frater, John; Furze, Julie; Galian-Rubio, Pablo; Galloway, Celine; Garlant, Harriet; Gavrila, Madita; Gibbons, Felicity; Gibbons, Karyna; Gilbride, Ciaran; Gill, Hardeep; Godwin, Kerry; Gordon-Quayle, Katherine; Gorini, Giacomo; Goulston, Lyndsey; Grabau, Caroline; Gracie, Lara; Graham, Nichola; Greenwood, Nicola; Griffiths, Oliver; Gupta, Gaurav; Hamilton, Elizabeth; Hanumunthadu, Brama; Harris, Stephanie A.; Harris, Tara; Harrison, Daisy; Hart, Thomas C.; Hartnell, Birgit; Haskell, Louise; Hawkins, Sophia; Henry, John Aaron; Herrera, Macarena Hermosin; Hill, David; Hill, Jennifer; Hodges, Gina; Hodgson, Susanne H.C.; Horton, Katie L.; Howe, Elizabeth; Howell, Nicola; Howes, Jessica; Huang, Ben; Humphreys, Jonathan; Humphries, Holly E.; Iveson, Poppy; Jackson, Frederic; Jackson, Susan; Jauregui, Sam; Jeffers, Helen; Jones, Bryony; Jones, Christine E.; Jones, Elizabeth; Jones, Kathryn; Joshi, Amar; Kailath, Reshma; Keen, Jade; Kelly, Dearbhla M.; Kelly, Sarah; Kelly, Debbie; Kerr, David; Khan, Liaquat; Khozoee, Baktash; Killen, Annabel; Kinch, Jasmin; King, Lloyd D.W.; King, Thomas B.; Kingham, Lucy; Klenerman, Paul; Knight, Julian C.; Knott, Daniel; Koleva, Stanislava; Lang, Gail; Larkworthy, Colin W.; Larwood, Jessica P.J.; Law, Rebecca; Lee, Arlene; Lee, Kim Y.N.; Lees, Emily A.; Leung, Stephanie; Li, Yuanyuan; Lias, Amelia M.; Linder, Aline; Lipworth, Samuel; Liu, Shuchang; Liu, Xinxue; Lloyd, Stephanie; Loew, Lisa; Ramon, Raquel Lopez; Madhavan, Meera; Mainwaring, David O.; Mallett, Garry; Mansatta, Kushal; Marinou, Spyridoula; Marius, Phedra; Marlow, Emma; Marriott, Paula; Marshall, Julia L.; Martin, Jane; Masters, Shauna; McEwan, Joanne; McGlashan, Joanna L.; McInroy, Lorna; McRobert, Nicky; Megson, Clare; Mentzer, Alexander J.; Mirtorabi, Neginsadat; Mitton, Celia; Moore, Maria; Moran, Marni; Morey, Ella; Morgans, Róisín; Morris, Susan J.; Morrison, Hazel Morrison; Morshead, Gertraud; Morter, Richard; Moya, Nathifa A.; Mukhopadhyay, Ekta; Muller, Jilly; Munro, Claire; Murphy, Sarah; Mweu, Philomena; Noé, Andrés; Nugent, Fay L.; O'Brien, Katie; O'Connor, Daniel; Oguti, Blanché; Olchawski, Victoria; Oliveira, Catarina; O'Reilly, Peter John; Osborne, Piper; Owen, Lydia; Owino, Nelly; Papageorgiou, Panagiotis; Parracho, Helena; Parsons, Karen; Patel, Bhumika; Patrick-Smith, Maia; Peng, Yanchun; Penn, Elizabeth J.; Peralta-Alvarez, Marco Polo; Perring, James; Petropoulos, Christos; Phillips, Daniel J.; Pipini, Dimitra; Pollard, Samuel; Poulton, Ian; Pratt, Danny; Presland, Laura; Proud, Pamela C.; Provstgaard-Morys, Samuel; Pueschel, Sophie; Pulido, David; Rabara, Ria; Radia, Kajal; Rajapaska, Durga; Lopez, Fernando Ramos; Ratcliffe, Helen; Rayhan, Sara; Rees, Byron; Pabon, Emilia Reyes; Roberts, Hannah; Robertson, Isla; Roche, Sophie; Rollier, Christine S.; Romani, Rossana; Rose, Zoe; Rudiansyah, Indra; Sabheha, Sabeha; Salvador, Stephannie; Sanders, Helen; Sanders, Katherine; Satti, Iman; Sayce, Chloe; Schmid, Annina B.; Schofield, Ella; Screaton, Gavin; Sedik, Cynthia; Seddiqi, Samiullah; Segireddy, Rameswara R.; Selby, Beatrice; Shaik, Imam; Sharpe, Hannah R.; Shaw, Robert; Shea, Adam; Silk, Sarah; Silva-Reyes, Laura; Skelly, Donal T.; Smith, David J.; Smith, Daniel C.; Smith, Nicholas; Spencer, Alexandra J.; Spoors, Louise; Stafford, Elizabeth; Stamford, Imogen; Stockdale, Lisa; Stockley, David; Stockwell, Lisa V.; Stokes, Matthew; Strickland, Louise H.; Stuart, Arabella; Sulaiman, Sulaiman; Summerton, Eloise; Swash, Zoe; Szigeti, Anna; Tahiri-Alaoui, Abdessamad; Tanner, Rachel; Taylor, Iona; Taylor, Keja; Taylor, Ursula; Naude, Rebecca te Water; Themistocleous, Andreas; Thomas, Merin; Thomas, Tonia M.; Thompson, Amber; Thompson, Kevin; Thornton-Jones, Viv; Tinh, Lan; Tomic, Adriana; Tonks, Susan; Towner, James; Tran, Nguyen; Tree, Julian A.; Truby, Adam; Turner, Cheryl; Turner, Richard; Ulaszewska, Marta; Varughese, Rachel; Verbart, Dennis; Verheul, Marije K.; Vichos, Iason; Walker, Laura; Wand, Matthew E.; Watkins, Bridget; Welch, Jessica; West, Alison J.; White, Caroline; White, Rachel; Williams, Paul; Woodyer, Mark; Worth, Andrew T.; Wright, Daniel; Wrin, Terri; Yao, Xin Li; Zbarcea, Diana-Andreea; Zizi, Dalila

doi:10.1016/s0140-6736(20)32466-1

articleThe LancetNov 19, 2020BRONZE OA

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

MNMaheshi N RamasamyAMAngela M MinassianKJKatie J EwerALAmy L FlaxmanPMPedro M Folegatti

Jenner Institute · University of Oxford · +5 more institutions

PubMed

Indexed incrossrefpubmed

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421

MN
Maheshi N RamasamyCorresponding
AM
Angela M Minassian
Jenner Institute, University of Oxford
KJ
Katie J Ewer
University of Oxford, Jenner Institute
AL
Amy L Flaxman
Jenner Institute, University of Oxford
PM
Pedro M Folegatti
Jenner Institute, University of Oxford

Topics & keywords

Topics

Keywords

Immunogenicity
Regimen
Clinical trial
Preparedness
Vaccination
Clinical research
MEDLINE
Public health

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