The Immune Functions of Keratinocytes in Skin Wound Healing
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Abstract
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair not only as structural cells but also exerting important immune functions. This review focuses on the communications between keratinocytes and immune cells in wound healing, which are mediated by various cytokines, chemokines, and extracellular vesicles. Keratinocytes can also directly interact with T cells via antigen presentation. Moreover, keratinocytes produce antimicrobial peptides that can directly kill the invading pathogens and contribute to wound repair in many aspects. We also reviewed the epigenetic mechanisms known to regulate keratinocyte immune functions, including histone modifications,…
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467
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Authors
3Topics & keywords
Topics
Keywords
- Wound healing
- Immune system
- Chemokine
- Keratinocyte
- Immunology
- Biology
- Inflammation
- Skin repair
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