Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity
Ghent University · Cancer Research Institute Ghent · +5 more institutions
Abstract
Background Immunotherapy represents the future of clinical cancer treatment. The type of cancer cell death determines the antitumor immune response and thereby contributes to the efficacy of anticancer therapy and long-term survival of patients. Induction of immunogenic apoptosis or necroptosis in cancer cells does activate antitumor immunity, but resistance to these cell death modalities is common. Therefore, it is of great importance to find other ways to kill tumor cells. Recently, ferroptosis has been identified as a novel, iron-dependent form of regulated cell death but whether ferroptotic cancer cells are immunogenic is unknown. Methods Ferroptotic cell death in murine fibrosarcoma MCA205 or glioma GL261…
Citation impact
- FWCI
- 26.71
- Percentile
- 100%
- References
- 85
Authors
14- IEIuliia Efimova
Ghent University, Cancer Research Institute Ghent
- ECElena Catanzaro
University of Bologna
- LVLouis Van der Meeren
Ghent University
- VDVictoria D. Turubanova
N. I. Lobachevsky State University of Nizhny Novgorod
- HHHamida Hammad
Ghent University Hospital, VIB-UGent Center for Inflammation Research
Topics & keywords
- Immunogenic cell death
- Immune system
- Cancer cell
- Cancer research
- Programmed cell death
- Immunogenicity
- Cancer
- Biology
- Good health and well-being