MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations

The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This catalogue was compiled using a Bayesian integration of multiple sequence features and experimental datasets, notably protein mass spectrometry of mitochondria isolated from fourteen murine tissues. Here, we introduce MitoCarta3.0. Beginning with the MitoCarta2.0 inventory, we performed manual review to remove 100 genes and introduce 78 additional genes, arriving at an updated inventory of 1136 human genes. We now include…

• NS
  National Science Foundation
• HH
  Howard Hughes Medical Institute
• MG
  Massachusetts General Hospital
• DF
  Deutsche Forschungsgemeinschaft

  Award: 431313887
• NI
  National Institutes of Health

  Awards: R35GM122455, K00CA212468, F32GM133047, F32GM128259, R01AR071942, K08DK115881, T32AG000222, T32DK007028
• JP
  Janssen Pharmaceuticals