CATH: increased structural coverage of functional space

Sillitoe, Ian; Bordin, Nicola; Dawson, Natalie L.; Waman, Vaishali; Ashford, Paul; Scholes, Harry; Pang, Camilla; Woodridge, Laurel; Rauer, Clemens; Sen, Neeladri; Abbasian, Mahnaz; Cornu, Sean Le; Lam, Su Datt; Berka, Karel; Vařeková, Ivana Hutařová; Vařeková, Radka Svobodová; Lees, Jonathan; Orengo, Christine

doi:10.1093/nar/gkaa1079

articleNucleic Acids ResearchNov 3, 2020GOLD OA

CATH: increased structural coverage of functional space

ISIan Sillitoe NBNicola Bordin NLNatalie L. Dawson VWVaishali Waman PAPaul Ashford

Institute of Structural and Molecular Biology · University College London · +7 more institutions

PubMed

Indexed incrossrefdatacitedoajpubmed

Abstract

CATH (https://www.cathdb.info) identifies domains in protein structures from wwPDB and classifies these into evolutionary superfamilies, thereby providing structural and functional annotations. There are two levels: CATH-B, a daily snapshot of the latest domain structures and superfamily assignments, and CATH+, with additional derived data, such as predicted sequence domains, and functionally coherent sequence subsets (Functional Families or FunFams). The latest CATH+ release, version 4.3, significantly increases coverage of structural and sequence data, with an addition of 65,351 fully-classified domains structures (+15%), providing 500 238 structural domains, and 151 million predicted sequence domains (+59%)…

Citation impact

551

total citations

FWCI: 63.70
Percentile: 100%
References: 30

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Authors

18

Topics & keywords

Topics

Cell Image Analysis Techniques98%

Keywords

Biology
Space (punctuation)
Computational biology
Computer science

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