Gut microbiota-derived metabolites as central regulators in metabolic disorders
AgroParisTech · Microbiologie de l’alimentation au service de la santé · +9 more institutions
Abstract
Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact with the host by the production of a diverse reservoir of metabolites, from exogenous dietary substrates or endogenous host compounds. Metabolic disorders are associated with alterations in the composition and function of the gut microbiota. Specific classes of microbiota-derived metabolites, notably bile acids, short-chain fatty acids, branched-chain amino acids, trimethylamine N-oxide, tryptophan and indole derivatives, have been implicated in the pathogenesis of metabolic disorders. This review aims to define the key classes of…
Citation impact
- FWCI
- 44.59
- Percentile
- 100%
- References
- 118
Authors
3- AAAllison AgusCorresponding
AgroParisTech, Microbiologie de l’alimentation au service de la santé, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Assistance Publique – Hôpitaux de Paris, Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
- KCKarine Clément
Inserm, Sorbonne Université, Nutrition et obésité : approches systémiques, Assistance Publique – Hôpitaux de Paris, Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine, Pitié-Salpêtrière Hospital
- HSHarry Sokol
Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine, Centre de Recherche Saint-Antoine
Topics & keywords
- Gut flora
- Metabolic pathway
- Pathogenesis
- Biology
- Microbiome
- Metabolomics
- Function (biology)
- Amino acid
- Good health and well-being