Head and neck squamous cell carcinoma
University of California, San Francisco · Yale Cancer Center · +4 more institutions
Abstract
Most head and neck cancers are derived from the mucosal epithelium in the oral cavity, pharynx and larynx and are known collectively as head and neck squamous cell carcinoma (HNSCC). Oral cavity and larynx cancers are generally associated with tobacco consumption, alcohol abuse or both, whereas pharynx cancers are increasingly attributed to infection with human papillomavirus (HPV), primarily HPV-16. Thus, HNSCC can be separated into HPV-negative and HPV-positive HNSCC. Despite evidence of histological progression from cellular atypia through various degrees of dysplasia, ultimately leading to invasive HNSCC, most patients are diagnosed with late-stage HNSCC without a clinically evident antecedent…
Citation impact
- FWCI
- 296.31
- Percentile
- 100%
- References
- 259
Authors
6Topics & keywords
- Medicine
- Head and neck squamous-cell carcinoma
- Cetuximab
- Pembrolizumab
- Larynx
- Oncology
- Nivolumab
- Head and neck cancer
- Good health and well-being
Funding
- IFImpact Fund
- FAFood and Health BureauAward: 15160691
- IAInnovation and Technology FundAward: UIM/329
- HKHong Kong Cancer Fund
- HKHong Kong Government
- NINational Institutes of HealthAwards: R01DE023685, P30CA023074, R35CA231998, U54CA209891, R01DE028289
- HAHealth and Medical Research FundAward: 15160691
- NCNational Cancer InstituteAwards: U54CA209891, UG1CA242596, R35CA231998, R01DE023685, P30CA023074, NCI P30CA023074