Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing

A two-pronged strategy of biomechanically active and biochemically functional hydrogel wound dressing which can assist wound closure and have multiple functions to promote wound healing has been rarely reported. Herein, we designed a series of biomechanically active injectable self-healing hydrogels based on quaternized chitosan (QCS), polydopamine-coated reduction graphene oxide (rGO-PDA), and poly(N-isopropylacrylamide) (PNIPAm) as multifunctional wound dressings to promote wound closure and wound healing. These biomechanically active wound dressings have excellent thermoresponsive self-contraction and tissue adhesion properties. They adhere strongly to the skin and assist wound closure by actively…

• NN
  National Natural Science Foundation of China

  Awards: 51673155, 51973172
• NS
  Natural Science Foundation of Shaanxi Province

  Awards: 2019TD-020, 2020JC-03