reviewJournal of Inflammation ResearchDec 1, 2020GOLD OA

<p>Reactive Oxygen Species: Drivers of Physiological and Pathological Processes</p>

JCJavier ChecaJMJosep M. Aran

Duran i Reynals Hospital · Institut d'Investigació Biomédica de Bellvitge

PubMed
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Abstract

Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a waste product of photosynthetic cyanobacteria, induced oxidative stress and the production of reactive oxygen species (ROS), which have since acted as fundamental drivers of biologic evolution and eukaryogenesis. Indeed, throughout an organism's lifespan, ROS affect directly (as mutagens) or indirectly (as messengers and regulators) all structural and functional components of cells, and many aspects of cell biology. Whether left unchecked by protective antioxidant systems, excess ROS not only cause genomic mutations but also induce…

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Topics & keywords

Topics
Keywords
  • Reactive oxygen species
  • Pathological
  • Chemistry
  • Oxygen
  • Internal medicine
  • Biochemistry
  • Medicine
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