Ferroptosis: molecular mechanisms and health implications
Third Affiliated Hospital of Guangzhou Medical University · Southwestern Medical Center · +13 more institutions
Abstract
Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis. Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway. Ferroptosis is caused by a redox imbalance between the production of oxidants and antioxidants, which is driven by the abnormal expression and activity of multiple redox-active enzymes that produce or detoxify free radicals and lipid oxidation products. Accordingly, ferroptosis is precisely regulated at multiple levels, including…
Citation impact
- FWCI
- 173.86
- Percentile
- 100%
- References
- 214
Authors
4- DTDaolin TangCorresponding
Third Affiliated Hospital of Guangzhou Medical University, Southwestern Medical Center, Key Laboratory of Guangdong Province, The University of Texas Southwestern Medical Center, Guangzhou Medical University
- XCXin Chen
Third Affiliated Hospital of Guangzhou Medical University, Southwestern Medical Center, Key Laboratory of Guangdong Province, Southwestern Medical Center, The University of Texas Southwestern Medical Center, Guangzhou Medical University
- RKRui Kang
Southwestern Medical Center, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- GKGuido Kroemer
Karolinska University Hospital, Inserm, Université Paris Cité, Institut Gustave Roussy, Sorbonne Université, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen, Suzhou Institute of Systems Medicine
Topics & keywords
- Neurodegeneration
- Programmed cell death
- Autophagy
- Cell biology
- Epigenetics
- Transcription factor
- Biology
- Apoptosis
- Good health and well-being
Funding
- APAssociation pour la Recherche sur le CancerAwards: R01CA211070, ANR-18-IDEX-0001, R01CA160417
- SFSeerave Foundation
- EE-Rare
- ECEuropean CommissionAwards: R01CA160417, R01CA211070
- ANAgence Nationale de la RechercheAwards: 18-IDEX-0001, -18-IDEX-0001, R01CA160417, UMS3655, ANR-18, R01CA211070, E-Rare-2
- FLFondation LeducqAwards: R01CA211070, R01CA160417
- INInstitut National de la Santé et de la Recherche MédicaleAward: ANR-18-IDEX-0001
- FPFondation pour la Recherche MédicaleAwards: R01CA211070, R01CA160417
- LCLigue Contre le CancerAwards: R01CA211070, R01CA160417
- CNCentre National de la Recherche ScientifiqueAwards: UMS3655, ANR-18-IDEX-0001
- IUInstitut Universitaire de FranceAwards: ANR-18-IDEX-0001, R01CA211070, R01CA160417
- INInstitut National Du CancerAwards: R01CA160417, R01CA211070, ANR-18-IDEX-0001
- IGInstitut Gustave-RoussyAward: UMS3655
- EREuropean Research Area Network on Cardiovascular Diseases
- NINational Institutes of HealthAwards: R01CA211070, R01CA160417, -0001, and R01CA211070
- HFHigh-end Foreign Experts Recruitment Plan of ChinaAward: GDW20171100085
- LILabex Immuno-OncologyAwards: R01CA211070, ANR-18-IDEX-0001, R01CA160417