Missing Data in Clinical Research: A Tutorial on Multiple Imputation
Sunnybrook Hospital · Institute for Clinical Evaluative Sciences · +7 more institutions
Abstract
Missing data is a common occurrence in clinical research. Missing data occurs when the value of the variables of interest are not measured or recorded for all subjects in the sample. Common approaches to addressing the presence of missing data include complete-case analyses, where subjects with missing data are excluded, and mean-value imputation, where missing values are replaced with the mean value of that variable in those subjects for whom it is not missing. However, in many settings, these approaches can lead to biased estimates of statistics (eg, of regression coefficients) and/or confidence intervals that are artificially narrow. Multiple imputation (MI) is a popular approach for addressing the presence…
Citation impact
- FWCI
- 58.26
- Percentile
- 100%
- References
- 38
Authors
4- PCPeter C. AustinCorresponding
Sunnybrook Hospital, Institute for Clinical Evaluative Sciences, Sunnybrook Research Institute, University of Toronto
- IRIan R. White
University College London, Medical Research Council
- DSDouglas S. Lee
Institute for Clinical Evaluative Sciences, University Health Network, University of Toronto
- SVStef van Buuren
Utrecht University, Netherlands Organisation for Applied Scientific Research
Topics & keywords
- Missing data
- Imputation (statistics)
- Statistics
- Medicine
- Regression analysis
- Sample size determination
- Data mining
- Confidence interval
Funding
- HAHeart and Stroke Foundation of CanadaAwards: MC_UU_12023/21, CTP79847, CRT43823
- IFInstitute for Clinical Evaluative SciencesAwards: CTP79847, MC_UU_12023/21, CRT43823
- OMOntario Ministry of Health and Long-Term CareAwards: CTP79847, MC_UU_12023/21, CRT43823
- CHChest Heart and Stroke ScotlandAwards: CTP79847, MC_UU_12023/21, CRT43823
- CICanadian Institutes of Health ResearchAwards: MC_UU_12023/21, CRT43823, 86508, MOP 86508, CTP79847
- MRMedical Research CouncilAwards: MC_UU_12023/21, CRT43823, CTP79847, MC_UU_12023/21