Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Rodrigues, Tamara Silva; Sá, Keyla Santos Guedes de; Ishimoto, Adriene Y.; Becerra, Amanda; Oliveira, Samuel; Almeida, Letícia de; Gonçalves, Augusto V.; Perucello, Debora B.; Andrade, Warrison A.; Castro, Ricardo Cardoso; Veras, Flávio P.; Toller-Kawahisa, Juliana E.; Nascimento, Daniele C.; Lima, Mikhael Haruo Fernandes de; Silva, Camila M.; Caetité, Diego B.; Martins, Ronaldo B.; Castro, Ítalo A.; Pontelli, Marjorie Cornejo; Barros, Fábio Cury de; Amaral, Natália B. do; Giannini, Marcela C; Bonjorno, Letícia Pastorelli; Lopes, Maria Isabel Fernandes; Santana, Rodrigo de Carvalho; Vilar, Fernando Crivelenti; Auxiliadora‐Martins, Maria; Assad, Rodrigo Luppino; Almeida, Sérgio C. L.; Oliveira, Fabíola Reis de; Batah, Sabrina Setembre; Siyuan, Li; Benatti, Maíra Nilson; Cunha, Thiago M.; Alves‐Filho, José C.; Cunha, Fernando Q.; Cunha, Larissa D.; Frantz, Fabiani Gai; Kohlsdorf, Tiana; Fabro, Alexandre Todorovic; Arruda, Eurico; Oliveira, Renê Donizeti Ribeiro de; Louzada‐Júnior, Paulo; Zamboni, Dario S.

doi:10.1084/jem.20201707

articleThe Journal of Experimental MedicineNov 11, 2020BRONZE OA

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

TSTamara Silva Rodrigues KSKeyla Santos Guedes de Sá AYAdriene Y. Ishimoto ABAmanda Becerra SOSamuel Oliveira

Universidade de São Paulo · Universidade de Ribeirão Preto · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular platform that promotes inflammation via cleavage and activation of key inflammatory molecules including active caspase-1 (Casp1p20), IL-1β, and IL-18. Although participation of the inflammasome in COVID-19 has been highly speculated, the inflammasome activation and participation in the outcome of the disease are unknown. Here we demonstrate that the NLRP3 inflammasome is activated in response to SARS-CoV-2 infection and is active in COVID-19 patients. Studying moderate and severe COVID-19 patients, we found active NLRP3 inflammasome in…

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850

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FWCI: 55.60
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Topics & keywords

Topics

Keywords

Inflammasome
Coronavirus disease 2019 (COVID-19)
Inflammation
Caspase 1
Medicine
Disease
Pathophysiology
Immunology

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