PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API

PANTHER (Protein Analysis Through Evolutionary Relationships, http://www.pantherdb.org) is a resource for the evolutionary and functional classification of protein-coding genes from all domains of life. The evolutionary classification is based on a library of over 15,000 phylogenetic trees, and the functional classifications include Gene Ontology terms and pathways. Here, we analyze the current coverage of genes from genomes in different taxonomic groups, so that users can better understand what to expect when analyzing a gene list using PANTHER tools. We also describe extensive improvements to PANTHER made in the past two years. The PANTHER Protein Class ontology has been completely refactored, and 6101…

• NS
  National Science Foundation

  Awards: 1458808, 1661543, 1917302
• NI
  National Institutes of Health

  Award: U41HG002273
• NC
  National Cancer Institute

  Award: P01CA196569